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The Medical Letter on Drugs and Therapeutics
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ISSUE
1545
Nebulized Glycopyrrolate (Lonhala Magnair) for COPD
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The FDA has approved an inhalation solution formulation of the long-acting antimuscarinic agent (LAMA) glycopyrrolate (Lonhala Magnair – Sunovion) for maintenance treatment of chronic obstructive pulmonary disease (COPD). The new formulation is delivered using a portable, handheld, electronic nebulizer. Glycopyrrolate is also available as a dry powder inhaler, both alone (Seebri Neohaler) and in combination with indacaterol (Utibron Neohaler), and as a metered-dose inhaler in combination with formoterol (Bevespi Aerosphere).1 Lonhala Magnair is the first nebulized LAMA to become available in the US.

CLINICAL STUDIES — The efficacy of nebulized glycopyrrolate was evaluated in two 12-week trials (GOLDEN 3 and 4) in 1294 patients with moderate to very severe COPD who were randomized to receive glycopyrrolate 25 mcg or 50 mcg or ... more      

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Title: Nebulized Glycopyrrolate (Lonhala Magnair) for COPD
Article code: 1545d
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