The Medical Letter on Drugs and Therapeutics
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1551
Baricitinib (Olumiant) for Rheumatoid Arthritis
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The FDA has approved the Janus kinase (JAK) inhibitor baricitinib (Olumiant – Lilly) for oral treatment of adults with moderately to severely active rheumatoid arthritis (RA) that has not responded adequately to one or more tumor necrosis factor (TNF) inhibitors. Baricitinib is the second JAK inhibitor to be approved for treatment of RA; tofacitinib (Xeljanz, Xeljanz XR) was the first.1

STANDARD TREATMENT — For initial treatment of RA, a disease-modifying antirheumatic drug (DMARD) is recommended to achieve clinical remission and prevent irreversible damage to joints; a nonsteroidal anti-inflammatory drug (NSAID) or a corticosteroid is usually added for symptom control. Methotrexate is generally the DMARD of choice; hydroxychloroquine and sulfasalazine are safer alternatives that may be appropriate in mild cases. Guidelines generally recommend use of a ... more      

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Title: Baricitinib (Olumiant) for Rheumatoid Arthritis
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