The Medical Letter on Drugs and Therapeutics
FROM
ISSUE 1581
ISSUE 1581
September 23, 2019
Issue 1581
- Lefamulin (Xenleta) for Community-Acquired Bacterial Pneumonia
- Glucagon Nasal Powder (Baqsimi) for Severe Hypoglycemia
- Duaklir Pressair: Another LAMA/LABA Inhaler for COPD
- Qmiiz ODT - An Orally Disintegrating Meloxicam Tablet
- In Brief: Ezallor Sprinkle - A New Formulation of Rosuvastatin
- Expanded Table: Statins (online only)
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Lefamulin (Xenleta) for Community-Acquired Bacterial Pneumonia
September 23, 2019 (Issue: 1581)
Lefamulin (Xenleta – Nabriva), a semisynthetic
pleuromutilin antibiotic, has been approved by the
FDA for IV and oral treatment of community-acquired
bacterial pneumonia (CABP) in adults. It is the first
systemic pleuromutilin antibiotic to be approved in the
US; retapamulin (Altabax), a 1% topical ointment for
treatment of impetigo, was approved in 2007.
... more
- Retapamulin (Altabax) - a new topical antibiotic. Med Lett Drugs Ther 2008; 50:13.
- S Jain et al. Community-acquired pneumonia requiring hospitalization among U.S. adults. N Engl J Med 2015; 373:415.
- In brief: more fluoroquinolone warnings. Med Lett Drugs Ther 2018; 60:136.
- LA Mandell et al. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis 2007; 44 Suppl 2:S27.
- Drugs for common bacterial infections in adults. Med Lett Drugs Ther 2017; 59:171.
- Omadacycline (Nuzyra) – a new tetracycline antibiotic. Med Lett Drugs Ther 2019; 61:74.
- KA Rodvold. Introduction: lefamulin and pharmacokinetic/pharmacodynamic rationale to support the dose selection of lefamulin. J Antimicrob Chemother 2019; 74(Suppl 3):iii2.
- S Paukner et al. In vitro activity of lefamulin against sexually transmitted bacterial pathogens. Antimicrob Agents Chemother 2018; 62:e02380.
- TM File Jr et al. Efficacy and safety of IV-to-oral lefamulin, a pleuromutilin antibiotic, for treatment of community-acquired bacterial pneumonia: The phase 3 LEAP 1 trial. Clin Infect Dis 2019 Feb 4 (epub).
- RL Woosley et al. QT drugs list. Available at: www.crediblemeds.org. Accessed September 12, 2019.

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