Treatment Guidelines from The Medical Letter
Drugs for Epilepsy
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Treatment of epilepsy should begin with a single drug, increasing the dosage gradually until seizures are controlled or adverse effects become unacceptable. If seizures continue and further dosage increases appear inadvisable because of adverse effects, most Medical Letter consultants generally prescribe at least one and sometimes a second alternative drug as monotherapy before considering use of two drugs at the same time. Most antiepileptic drugs initially approved by the FDA only as adjunctive therapy for partial seizures may also be effective for other types of seizures and as monotherapy.1,2 Studies suggest that when used for the appropriate seizure type, antiepileptic drugs are roughly equivalent in efficacy.1-4 The choice of a drug is usually based on factors such as ease of use, adverse effects and cost.

The treatment of status epilepticus is not included here. Most of the interactions ... more      

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.

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Title: Drugs for Epilepsy
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