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Epsolay - A Benzoyl Peroxide Cream for Rosacea
The Medical Letter on Drugs and Therapeutics • Feb 06, 2023 (Issue 1669)
disease, an
oral antibiotic such as doxycycline can be used.1-3
THE NEW FORMULATION — In Epsolay ...
Epsolay (Galderma), a 5% benzoyl peroxide cream,
has been approved by the FDA for treatment of
inflammatory lesions of rosacea in adults. It is the first
product containing benzoyl peroxide to be approved
in the US for treatment of rosacea. Benzoyl peroxide
formulations approved for acne have been used off-label
to treat rosacea for years, but itching and burning
have limited their use.
Med Lett Drugs Ther. 2023 Feb 6;65(1669):21-2 doi:10.58347/tml.2023.1669c | Show Introduction Hide Introduction
COVID-19 Vaccine Comparison Chart (Archived) (online only)
The Medical Letter on Drugs and Therapeutics • Apr 05, 2021 (Issue 1621)
doses (0.3 mL)
21 days apart 2 doses (0.5 mL)
28 days apart 1 dose (0.5 mL)
2 doses
4-12 weeks ...
View the COVID-19 Vaccine Comparison Chart
Talicia - A 3-Drug Combination for Helicobacter pylori Infection
The Medical Letter on Drugs and Therapeutics • Jun 01, 2020 (Issue 1599)
patient adherence to multidrug
regimens.1 When available, susceptibility testing
should be used to guide ...
The FDA has approved a fixed-dose combination
of omeprazole, amoxicillin, and rifabutin (Talicia –
RedHill) for treatment of Helicobacter pylori infection
in adults. Talicia is the first rifabutin-based product to
be approved for this indication.
Oriahnn for Fibroid-Associated Heavy Menstrual Bleeding
The Medical Letter on Drugs and Therapeutics • Apr 05, 2021 (Issue 1621)
) has been
available since 2018 for treatment of moderate to
severe pain associated with endometriosis.1 The
GnRH ...
Oriahnn (Abbvie), a fixed-dose combination of the
gonadotropin-releasing hormone (GnRH) receptor
antagonist elagolix, the estrogen estradiol, and the
progestin norethindrone acetate copackaged with
elagolix alone, has been approved by the FDA for oral
treatment of heavy menstrual bleeding associated
with uterine leiomyomas (fibroids) in premenopausal
women. It is the first product to be approved in the
US for this indication. Elagolix (Orilissa) has been
available since 2018 for treatment of moderate to
severe pain associated with endometriosis. The
GnRH receptor antagonist...
Myfembree for Fibroid-Associated Heavy Menstrual Bleeding
The Medical Letter on Drugs and Therapeutics • Aug 09, 2021 (Issue 1630)
antagonist elagolix in combination with estradiol and
norethindrone acetate, was approved earlier.1 ...
Myfembree (Myovant/Pfizer), an oral fixed-dose
combination of the gonadotropin-releasing hormone
(GnRH) receptor antagonist relugolix, the estrogen
estradiol, and the progestin norethindrone acetate,
has been approved by the FDA for management of
heavy menstrual bleeding associated with uterine
leiomyomas (fibroids) in premenopausal women. It is
the second product to be approved in the US for this
indication; Oriahnn, which contains the GnRH receptor
antagonist elagolix in combination with estradiol and
norethindrone acetate, was approved earlier. Relugolix
was approved for...
Zavegepant (Zavzpret) for Acute Treatment of Migraine
The Medical Letter on Drugs and Therapeutics • Jul 24, 2023 (Issue 1681)
prevention.1,2 Atogepant (Qulipta), another oral
CGRP receptor antagonist, and four parenterally ...
The FDA has approved zavegepant nasal spray
(Zavzpret – Pfizer) for acute treatment of migraine
with or without aura in adults. Zavzpret is the first
nasal spray formulation of a calcitonin gene-related
peptide (CGRP) receptor antagonist ("gepant") to
become available in the US.
Med Lett Drugs Ther. 2023 Jul 24;65(1681):116-8 doi:10.58347/tml.2023.1681c | Show Introduction Hide Introduction
Elexacaftor/Tezacaftor/Ivacaftor (Trikafta) for Cystic Fibrosis
The Medical Letter on Drugs and Therapeutics • Jan 13, 2020 (Issue 1589)
approval for elexacaftor.
Ivacaftor is available alone (Kalydeco)1 and in
2-drug combinations ...
The FDA has approved Trikafta (Vertex), a fixed-dose
combination of the cystic fibrosis transmembrane
conductance regulator (CFTR) modulators elexacaftor,
tezacaftor, and ivacaftor, for oral treatment of cystic
fibrosis (CF) in patients ≥12 years old who have at
least one Phe508del mutation in the CFTR gene. About
90% of patients with CF have at least one copy of the
Phe508del (also called F508del) mutation. This is the
first approval for elexacaftor. Ivacaftor is available
alone (Kalydeco) and in 2-drug combinations with
tezacaftor (Symdeco) and lumacaftor...
Lasmiditan (Reyvow) and Ubrogepant (Ubrelvy) for Acute Treatment of Migraine
The Medical Letter on Drugs and Therapeutics • Mar 09, 2020 (Issue 1593)
for treatment of
moderate to severe migraine.1 The pain freedom rate
at 2 hours after administration ...
Lasmiditan (Reyvow – Lilly), an oral serotonin
(5-HT1F) receptor agonist, and ubrogepant (Ubrelvy –
Allergan), an oral calcitonin gene-related peptide
(CGRP) receptor antagonist, have been approved
by the FDA for acute treatment of migraine with or
without aura in adults.
Addendum: Estradiol/Progesterone (Bijuva) for Menopausal Vasomotor Symptoms
The Medical Letter on Drugs and Therapeutics • Jul 29, 2019 (Issue 1577)
Lett Drugs Ther 2019;
61:99), Table 1 should have included single-ingredient oral
formulations ...
In our article on Bijuva, the oral fixed-dose combination of estradiol and progesterone (Med Lett Drugs Ther 2019; 61:99), Table 1 should have included single-ingredient oral formulations of estradiol and progesterone (see below). They will be added to the table as it appears online, along with medroxyprogesterone (Provera, and generics), another single-ingredient progestin available for use in women with an intact uterus who take systemic estrogen for menopausal symptoms. Taking generic estradiol and progesterone separately may be less convenient than taking Bijuva, but they cost less and...
Expanded Table: Drugs for Malaria Prophylaxis (online only)
The Medical Letter on Drugs and Therapeutics • Jul 01, 2019 (Issue 1575)
Pediatric
1 adult tab (250/100 mg)
once/day
5-8 kg: ½ ped tab/day (1 ped
tab is 62.5/25 mg)
9-10 kg ...
View the Expanded Table: Drugs for Prophylaxis of Malaria