The FDA has approved baxdrostat (Baxfendy – AstraZeneca), an oral aldosterone synthase inhibitor, for add-on treatment of hypertension in adults whose blood pressure is not adequately controlled on other drugs. Baxdrostat is the first aldosterone synthase inhibitor to become available in the US.
STANDARD TREATMENT — Hypertension is considered resistant when it remains uncontrolled despite optimal treatment with three or more drugs, including a diuretic; a typical three-drug regimen consists of an angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB), a calcium...
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RELEASE
Differin Epiduo gel (Galderma), a fixed-dose combination of the synthetic retinoid adapalene 0.1% and the oxidizing agent benzoyl peroxide 2.5%, is now available over the counter (OTC) for topical treatment of acne in patients ≥12 years old. The gel will remain available by prescription in the same strength for use in patients 9-11 years old. A gel containing adapalene 0.3% and benzoyl peroxide 2.5% (Epiduo Forte, and generics) is available by prescription for use in patients ≥12 years old.
PHARMACOLOGY — Topical retinoids are often used for first-line treatment of acne, either alone or in combination with a topical antibiotic or topical benzoyl peroxide, which also has antibacterial activity. Adapalene modulates keratinization, inflammation, and differentiation of follicular epithelial cells, decreasing formation of comedones and inflammatory lesions. Retinoid/antimicrobial combinations …