Lipid-lowering drugs should be taken indefinitely; when they are stopped, plasma lipoproteins return to pretreatment levels. HMG-CoA reductase inhibitors (statins) remain the drugs of choice for treatment of most patients who require lipid-lowering therapy.
STATINS — Statins block the rate-limiting step in cholesterol synthesis. The subsequent reduction in hepatic cholesterol causes upregulation of lowdensity lipoprotein (LDL) receptors, increasing uptake and clearance of LDL-cholesterol (LDL-C) from the blood. Statins also decrease very low-density lipoprotein cholesterol (VLDL-C) and triglyceride levels and modestly increase high-density lipoprotein cholesterol (HDL-C) levels. Other direct effects of statins or indirect effects of lowering cholesterol include improved endothelial function, decreased platelet aggregation, and reduced inflammation. Statins also decrease serum concentrations of C-reactive protein, a marker of...
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The FDA recently announced that it will require the labeling of all direct-acting antiviral drugs used for treatment of hepatitis C virus (HCV) infection to include a boxed warning about a risk of hepatitis B virus (HBV) reactivation associated with their use.1
Twenty-four cases of HBV reactivation occurring during treatment with direct-acting antiviral drugs for HCV were identified from the FDA Adverse Event Reporting System and the medical literature.2-5 Before starting direct-acting antiviral ...