Brivaracetam (Briviact) for Epilepsy
Brivaracetam (Briviact) for Epilepsy
July 18, 2016 (Issue: 1499)
Brivaracetam (Briviact – UCB), an analog of
levetiracetam (Keppra, and others), has been approved
by the FDA for adjunctive treatment of partial-onset
seizures in patients ≥16 years old. New drugs for
epilepsy are often approved initially...more
- Drugs for epilepsy. Treat Guidel Med Lett 2013; 11:9.
- L Mumoli et al. Brivaracetam: review of its pharmacology and potential use as adjunctive therapy in patients with partial onset seizures. Drug Des Devel Ther 2015; 9:5719.
- P Ryvlin et al. Adjunctive brivaracetam in adults with uncontrolled focal epilepsy: results from a double-blind, randomized, placebo-controlled trial. Epilepsia 2014; 55:47.
- V Biton et al. Brivaracetam as adjunctive treatment for uncontrolled partial epilepsy in adults: a phase III randomized, double-blind, placebo-controlled trial. Epilepsia 2014; 55:57.
- P Klein et al. A randomized, double-blind, placebo-controlled, multicenter, parallel-group study to evaluate the efficacy and safety of adjunctive brivaracetam in adult patients with uncontrolled partial-onset seizures. Epilepsia 2015; 56:1890.
- P Kwan et al. Adjunctive brivaracetam for uncontrolled focal and generalized epilepsies: results of a phase III, double-blind, randomized, placebo-controlled, flexible-dose trial. Epilepsia 2014; 55:38.
- R Kälviäinen et al. Brivaracetam in Unverricht-Lundborg disease (EPM1): results from two randomized, double-blind, placebo-controlled studies. Epilepsia 2016; 57:210.
- Inhibitors and inducers of CYP enzymes and P-glycoprotein. Med Lett Drugs Ther 2016; 58:e46.
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