Smoking tobacco remains the primary preventable cause of death in the US. Smoking cessation often requires both pharmacotherapy and behavioral support.1,2
NICOTINE REPLACEMENT — All FDA-approved nicotine replacement therapies (NRTs) deliver nicotine to nicotinic acetylcholine receptors in the central nervous system (CNS) in a lower dose and at a substantially slower rate than tobacco cigarettes and electronic nicotine delivery systems. Nicotine undergoes extensive first-pass metabolism, which limits its effectiveness in oral formulations. Nicotine gum, lozenges,...
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Smoking tobacco remains the primary preventable cause of death in the US. Smoking cessation often requires both pharmacotherapy and behavioral support.1,2
NICOTINE REPLACEMENT — All FDA-approved nicotine replacement therapies (NRTs) deliver nicotine to nicotinic acetylcholine receptors in the central nervous system (CNS) in a lower dose and at a substantially slower rate than tobacco cigarettes and electronic nicotine delivery systems. Nicotine undergoes extensive first-pass metabolism, which limits its ...
