CURRENT
ISSUE
1576

Smoking tobacco remains the primary preventable cause of death in the US. Smoking cessation often requires both pharmacotherapy and behavioral support.1,2

NICOTINE REPLACEMENT — All FDA-approved nicotine replacement therapies (NRTs) deliver nicotine to nicotinic acetylcholine receptors in the central nervous system (CNS) in a lower dose and at a substantially slower rate than tobacco cigarettes and electronic nicotine delivery systems. Nicotine undergoes extensive first-pass metabolism, which limits its effectiveness in oral formulations. Nicotine gum, lozenges,...  Continue reading

More from Issue 1576
Previous Issue: 1575      July 1, 2019
Coming Soon
Cyclosporine (Cequa) for Dry Eye
Fluticasone Propionate (Xhance) for Nasal Polyps
One-Time Gene Therapy for Spinal Muscular Atrophy
Cladribine (Mavenclad) for Multiple Sclerosis
Drugs for Anxiety
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FROM
ISSUE
1575

Smoking tobacco remains the primary preventable cause of death in the US. Smoking cessation often requires both pharmacotherapy and behavioral support.1,2

NICOTINE REPLACEMENT — All FDA-approved nicotine replacement therapies (NRTs) deliver nicotine to nicotinic acetylcholine receptors in the central nervous system (CNS) in a lower dose and at a substantially slower rate than tobacco cigarettes and electronic nicotine delivery systems. Nicotine undergoes extensive first-pass metabolism, which limits its ... Continue reading