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1555

The FDA has approved Roxybond (Daiichi Sankyo), an immediate-release (IR) oxycodone formulation with abuse-deterrent properties, for treatment of pain requiring management with an opioid. Roxybond is the first IR opioid to be approved as an abuse-deterrent product. Oxaydo, another IR oxycodone formulation, has properties that discourage its intranasal and intravenous use, but is not considered an abuse-deterrent product by the FDA. Use of opioids for treatment of pain was reviewed in a recent issue.1

ABUSE-DETERRENT OPIOIDS — Abuse-deterrent opioid formulations have properties that make their intentional nontherapeutic use more difficult, less attractive, and less rewarding, but they are expensive, and whether they reduce overall opioid abuse remains to be determined. No oral opioid formulation prevents consumption of intact dosage units.2,3

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More from Issue 1555
Previous Issue: 1554      August 27, 2018
Coming Soon
Antiviral Drugs for Varicella-Zoster Virus and Herpes Simplex Virus Infections
Elagolix (Orilissa) - An Oral GnRH Antagonist for Endometriosis Pain
Hydrogen Peroxide 40% (Eskata) for Seborrheic Keratoses
Choice of Contraceptives
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FROM
ISSUE
1555

The FDA has approved an estradiol softgel vaginal insert (Imvexxy – TherapeuticsMD) for treatment of postmenopausal women with moderate to severe dyspareunia due to vulvovaginal atrophy (VVA). Imvexxy is the second estradiol vaginal insert to be approved in the US; Vagifem, an intravaginal tablet formulation, was the first.1 Vagifem and Imvexxy are both available in inserts containing 10 mcg of estradiol; Imvexxy is also available in a 4-mcg strength.

TREATMENT OF DYSPAREUNIA — VVA is caused by a loss of estrogen in postmenopausal women.2 Symptoms of VVA include vaginal dryness, vaginal irritation, and dyspareunia.3 Over-the-counter vaginal moisturizers (Replens, and ... Continue reading