The FDA has approved Xultophy 100/3.6 (Novo Nordisk), a fixed-ratio combination of insulin degludec and the GLP-1 (glucagon-like peptide-1) receptor agonist liraglutide, for once-daily treatment of adults with type 2 diabetes inadequately controlled on basal insulin (<50 units daily) or liraglutide (≤1.8 mg daily).

Soliqua 100/33, a long-acting insulin/GLP-1 receptor agonist combination that contains insulin glargine (Lantus, and others) and lixisenatide (Adlyxin), has also recently become available in the US.1 

GLP-1 RECEPTOR AGONISTS — GLP-1 receptor agonists lower glucose levels by potentiating glucose-dependent insulin secretion, suppressing postprandial glucagon secretion, slowing gastric emptying, and promoting satiety. They lower glycated hemoglobin (A1C) by about 1-1.5%, have been associated with weight loss of 1.5-2.8 kg, and rarely cause hypoglycemia.Continue reading

More from Issue 1529
Previous Issue: 1528      August 28, 2017
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Drugs for Cognitive Loss and Dementia
Influenza Vaccine for 2017-2018
Two New Combinations for Chronic HCV Infection - Vosevi and Mavyret
Guselkumab (Tremfya) for Psoriasis
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The FDA has approved the steroid prasterone (Intrarosa – Endoceutics) for intravaginal treatment of postmenopausal women with moderate-to-severe dyspareunia due to vulvovaginal atrophy (VVA). Also called dehydroepiandrosterone (DHEA), prasterone is produced in the adrenal glands, gonads, and brain and converted intracellularly into active metabolites of estrogens and androgens. DHEA has been available over the counter for years as an oral dietary supplement claimed to benefit sexual, cardiovascular, and neuropsychiatric dysfunction.Continue reading