The FDA has licensed Capvaxive (PCV21; Merck), a 21-valent pneumococcal conjugate vaccine, for prevention of invasive pneumococcal disease (IPD) and pneumococcal pneumonia in adults. Four other pneumococcal vaccines are currently available in the US: Prevnar 20 (PCV20), Vaxneuvance (PCV15), and Prevnar 13 (PCV13) are conjugate vaccines licensed for use in persons ≥6 weeks old, and Pneumovax 23 (PPSV23) is a pneumococcal polysaccharide vaccine licensed for use in persons ≥2 years old (see Table 1).1
- An Epinephrine Nasal Spray (neffy) for Anaphylaxis
- Vonoprazan (Voquezna) for Nonerosive GERD
- A New RSV Vaccine (mResvia) for Adults ≥60 Years Old
- In Brief: New Warning for Fezolinetant (Veozah)
- Figure 1: Pneumococcal Vaccine Recommendations for Adults 19-64 Years Old (online only)
- Figure 2: Pneumococcal Vaccine Recommendations for Adults ≥65 Years Old (online only)
- Addendum: Effectiveness of mRNA COVID-19 Vaccines (online only)
- In Brief: Afamitresgene Autoleucel (Tecelra) for Synovial Sarcoma (online only)
- In Brief: Erzofri — Another Once-Monthly Paliperidone Formulation (online only)
RELEASE
The FDA has authorized over-the-counter (OTC) sale of a nonmedicated alcohol-based gel (Eroxon – Futura) for treatment of erectile dysfunction (ED) in males ≥22 years old. Eroxon is the only FDA-approved OTC and topical treatment for erectile dysfunction. It is also available in the UK and the EU.
STANDARD TREATMENT ― Oral phosphodiesterase type 5 (PDE5) inhibitors such as avanafil (Stendra), sildenafil (Viagra, and generics), tadalafil (Cialis, and generics), and vardenafil (Levitra, and generics) are usually tried first for treatment of ED. The onset of action is about 30-45 minutes for each of these drugs. PDE5 inhibitors can cause headache, flushing, and back pain, and they have been associated with sudden losses of vision and hearing. All PDE5 inhibitors are substrates of CYP3A4, …