Smoking tobacco remains the primary preventable cause of death in the US. Smoking cessation often requires both pharmacotherapy and behavioral support.1,2

NICOTINE REPLACEMENT — All FDA-approved nicotine replacement therapies (NRTs) deliver nicotine to nicotinic acetylcholine receptors in the central nervous system (CNS) in a lower dose and at a substantially slower rate than tobacco cigarettes and electronic nicotine delivery systems. Nicotine undergoes extensive first-pass metabolism, which limits its effectiveness in oral formulations. Nicotine gum, lozenges,...  Continue reading

Most colorectal cancers arise from localized adenomatous polyps in a process that may take 10 years or more. Early detection and removal of a precancerous colonic lesion (polyp) can prevent cancer from developing. ... Continue reading