Cefiderocol (Fetroja) - A New IV Cephalosporin for Complicated UTI
Cefiderocol (Fetroja) - A New IV Cephalosporin for Complicated UTI
May 4, 2020 (Issue: 1597)
The FDA has approved cefiderocol (Fetroja – Shionogi),
a new IV cephalosporin antibiotic, for treatment of
complicated urinary tract infections (UTI) caused by
susceptible gram-negative bacteria in adults who
have limited or no alternative...more
- Ceftazidime/avibactam (Avycaz) – a new intravenous antibiotic. Med Lett Drugs Ther 2015; 57:79.
- Ceftolozane/tazobactam (Zerbaxa) – a new intravenous antibiotic. Med Lett Drugs Ther 2015; 57:31.
- Meropenem/vaborbactam (Vabomere) for complicated urinary tract infection. Med Lett Drugs Ther 2018; 60:103.
- JJ Choi and MW McCarthy. Cefiderocol: a novel siderophore cephalosporin. Expert Opin Investig Drugs 2018; 27:193.
- GG Zhanel et al. Cefiderocol: a siderophore cephalosporin with activity against carbapenem-resistant and multidrug-resistant gram-negative bacilli. Drugs 2019; 79:271.
- S Portsmouth et al. Cefiderocol versus imipenem-cilastatin for the treatment of complicated urinary tract infections caused by Gram-negative uropathogens: a phase 2, randomised, doubleblind, non-inferiority trial. Lancet Infect Dis 2018; 18:1319.
- RG Wunderink et al. LB4. Efficacy and safety of cefiderocol vs high-dose meropenem in patients with nosocomial pneumonia – results of a phase 3, randomized, multicenter, double-blind, noninferiority study. Open Forum Infect Dis 2019; 6(suppl 2):S994. Available at: https://bit.ly/2VrgMea. Accessed April 23, 2020.
- FDA briefing document. Cefiderocol injection. Meeting of the Antimicrobial Drugs Advisory Committee (AMDAC). October 16, 2019. Available at: https://bit.ly/3cjPflD. Accessed April 23, 2020.
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