Once-Weekly Insulin Icodec (Awiqli) for Type 2 Diabetes
Once-Weekly Insulin Icodec (Awiqli) for Type 2 Diabetes
August 28, 2026 (Issue: 5132)
Insulin icodec (Awiqli – Novo Nordisk), an ultra-long-acting
basal human insulin analog, has been approved
by the FDA for once weekly treatment of type 2 diabetes.
Two once-daily, long-acting insulin analogs are available
in the US: glargine...more
- American Diabetes Association Professional Practice Committee. Introduction and methodology: standards of care in diabetes – 2025. Diabetes Care 2025; 48(Suppl. 1):S1. doi:10.2337/dc25-sint
- Insulins for type 2 diabetes. Med Lett Drugs Ther 2025; 67:196.
- J Rosenstock et al. Weekly icodec versus daily glargine U100 in type 2 diabetes without previous insulin. N Engl J Med 2023; 389:297. doi:10.1056/nejmoa2303208
- I Lingvay et al. Once-weekly insulin icodec vs once-daily insulin degludec in adults with insulin-naïve type 2 diabetes: the ONWARDS 3 randomized clinical trial. JAMA 2023; 330:228. doi:10.1001/jama.2023.11313
- A Philis-Tsimikas et al. Switching to once-weekly insulin icodec versus once-daily insulin degludec in individuals with basal insulin-treated type 2 diabetes (ONWARDS 2): a phase 3a, randomised, open label, multicentre, treat-to-target trial. Lancet Diabetes Endocrinol 2023; 11:414. doi:10.1016/s2213-8587(23)00093-1
- C Mathieu et al. Switching to once-weekly insulin icodec versus once-daily insulin glargine U100 in individuals with basal-bolus insulin-treated type 2 diabetes (ONWARDS 4): a phase 3a, randomised, open-label, multicentre, treat-to-target, non-inferiority trial. Lancet 2023; 401:1929. doi:10.1016/s0140-6736(23)00520-2
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