Treatment Guidelines from The Medical Letter
Drugs for HIV Infection
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Guidelines for use of antiretroviral agents continue to shift toward earlier and more continuous treatment, both to treat the patient and to prevent transmission of the disease to others.1-3 Resistance testing is now recommended when antiretroviral drugs are started.4 Increases in HIV RNA levels ("viral load") while on therapy may indicate development of drug resistance, requiring further testing and a change in the treatment regimen. Antiretroviral drugs interact with each other and with many other drugs; complete information on these interactions is available at

Antiretroviral treatment regimens usually include a "backbone" and a "base". The backbone is typically two nucleoside reverse transcriptase inhibitors (NRTIs). The base can be a non-nucleoside reverse transcriptase inhibitor (NNRTI), a protease inhibitor (PI), ... more      

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.

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Title: Drugs for HIV Infection
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