Treatment Guidelines from The Medical Letter
Drugs for Postmenopausal Osteoporosis
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RECOMMENDATIONS — Calcium supplements can decrease the risk of osteoporosis in patients with an inadequate intake of calcium and vitamin D. There is no evidence that patients with an adequate dietary intake of calcium and vitamin D will benefit from taking supplements.Oral bisphosphonates can prevent vertebral and nonvertebral fractures in postmenopausal women with osteoporosis. Weekly or monthly doses of oral bisphosphonates are as effective as daily doses in increasing bone mineral density (BMD) and probably better tolerated, but fracture data are available only for once-daily formulations. IV administration of ibandronate every 3 months or zoledronic acid once a year is another alternative. The optimal duration of bisphosphonate therapy is unclear; available data, which are limited, indicate that some women continue to benefit from taking a bisphosphonate for as long as 10 years, and the benefit may outweigh the low risk of ... more      
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Title: Drugs for Postmenopausal Osteoporosis
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