Treatment Guidelines from The Medical Letter
Antifungal Drugs
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The drugs of choice for treatment of fungal infections are listed in Table 1. Some of the indications and dosages recommended here have not been approved by the FDA. More detailed guidelines for some of these infections are available online from the Infectious Diseases Society of America (


Azole antifungal agents inhibit synthesis of ergosterol, an essential component of the fungal cell membrane. They vary in their spectrum of activity, oral bioavailability, adverse effects and potential for drug-drug interactions.

FLUCONAZOLE — Fluconazole (Diflucan, and others) is active against most Candida species other than C. krusei, which is intrinsically resistant, and many strains of C. glabrata, which are variably resistant. It has good activity ... more      

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.

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