The Medical Letter on Drugs and Therapeutics
Ramelteon (Rozerem) for Insomnia
Subscribers: Log in to read full article.  Not a subscriber?  Subscribe or purchase article.

Ramelteon (Rozerem – Takeda), a melatonin receptor agonist, has been approved by the FDA for treatment of insomnia characterized by difficulty falling asleep. Unlike all other prescription hypnotics, which are classified as schedule IV drugs, ramelteon is not a controlled substance.

DRUGS FOR INSOMNIA — Melatonin itself is available in the US only as a “dietary supplement”.1 Its effectiveness as a hypnotic remains to be established, and the potency and purity of the commercial preparations are suspect.

First-generation antihistamines such as diphenhydramine (Nytol, and others) are available as “sleepaids” without a prescription. Tolerance to their sedative effects may develop rapidly, and they can cause nextday sedation. Benzodiazepines and nonbenzodiazepine drugs that act on the benzodiazepine component of the GABA-A receptor are the most commonly used prescription ... more      

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.

Would you like to read the rest of this article?  Gain access below.

Subscriptions to The Medical Letter on Drugs and Therapeutics include:
  • Print version published and mailed biweekly (26 issues/year)
  • Unlimited online access to current and past issues (1988 - present)
  • Mobile App for iOS, Android, and Kindle Fire
  • FREE online per issue CME/CE
Purchase this article:
Title: Ramelteon (Rozerem) for Insomnia
Article code: 1221a
 Electronic, downloadable article - $45
Gain access through your organization
Ask your librarian to consider an Institutional Subscription to The Medical Letter.
Recommend to your librarian