The Medical Letter on Drugs and Therapeutics
A Combination of Oxycodone and Ibuprofen (Combunox) for Pain
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A fixed-dose combination of oxycodone 5 mg and ibuprofen 400 mg (Combunox – Forest Laboratories) is now available and is being heavily advertised for short-term treatment of moderate to severe acute pain.

THE DRUGSOxycodone is a semisynthetic opioid analgesic structurally related to morphine and codeine. It is about 1.5 times more potent than hydrocodone and 7.0-9.5 times more potent than oral codeine for relief of pain. Single-entity oxycodone is available in the US as immediate-release and controlled-release tablets (Oxycontin) and in liquid formulations. Oral oxycodone has been available in the US since the 1950’s in combination with aspirin (Percodan) or acetaminophen (Percocet, and others).

Ibuprofen, a nonselective nonsteroidal anti-inflammatory drug (NSAID), is available by prescription and in lower-strength over-the-counter formulations. A 400-mg dose ... more      

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