The Medical Letter on Drugs and Therapeutics
Clobetasol Propionate (Clobex) Spray for Psoriasis
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The FDA has approved a new spray formulation of the super-high-potency corticosteroid clobetasol propionate 0.05% (Clobex – Galderma) for treatment of moderate to severe plaque psoriasis in adults. Clobetasol propionate is also available as a cream, ointment, gel, solution, foam, lotion and shampoo.

TOPICAL CORTICOSTEROIDS FOR PSORIASIS — Topical corticosteroids are the most widely used drugs for treatment of psoriasis.1 For many years, pharmaceutical manufacturers have used the ability of topical corticosteroids to induce vasoconstriction in normal human skin as a measure of their clinical potency. Vasoconstrictor assays generally correlate with antiinflammatory activity. Topical corticosteroids vary in potency from the super-high-potency drugs listed in the table to the least potent 0.5% hydrocortisone.

VEHICLES — Ointments are generally considered the ... more      

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