The Medical Letter on Drugs and Therapeutics
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1238
A Betamethasone-Calcipotriene Combination for Psoriasis
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Taclonex ointment (Warner Chilcott/LEO Pharma), a combination of the vitamin D3 analog calcipotriene 0.005% (Dovonex) and the high-potency corticosteroid betamethasone dipropionate 0.064%, was recently approved by the FDA for treatment of psoriasis vulgaris in patients ≥18 years old.

BACKGROUND — Topical corticosteroids are the mainstay of treatment for psoriasis. When used alone, calcipotriene (called calcipotriol outside the US) is about as effective in treating psoriasis as a medium-potency steroid.1 When calcipotriene is used in combination with a potent topical corticosteroid, each applied once a day at different times, efficacy is better than treatment with either one alone. Calcipotriene is inactivated by acid pH and may not be stable when applied with some other topical products.2

CLINICAL STUDIES — A double-blind study in ... more      

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Title: A Betamethasone-Calcipotriene Combination for Psoriasis
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