The Medical Letter on Drugs and Therapeutics
A Low-Dose Doxycycline (Oracea) for Rosacea
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A new once-daily, low-dose oral formulation of doxycycline monohydrate (Oracea – CollaGenex) has been approved by the FDA for treatment of inflammatory papules and pustules associated with rosacea in adults.

STANDARD TREATMENT —What role, if any, bacteria play in the etiology of rosacea is unknown, but both topical and oral antibacterials are often used to treat it.1 Oral antibiotics tend to be effective for treatment of papules, pustules, erythema and ocular inflammation, but not for telangiectasia, rhinophyma, or the flushing that generally occurs in this disorder. Prolonged courses (months or sometimes years), which are often needed, can lead to bacterial resistance.2

MECHANISM OF ACTION — The efficacy of tetracyclines such as doxycycline in rosacea may be due to their anti-angiogenic and anti-inflammatory properties, rather than an ... more      

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Title: A Low-Dose Doxycycline (Oracea) for Rosacea
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