The Medical Letter on Drugs and Therapeutics
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1258
Subcutaneous Immune Globulin (SCIG)
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Some patients with primary immune deficiency are injected with intravenous immune globulin (IVIG) every 3-4 weeks.1 Now a subcutaneous immune globulin (SCIG) has also been approved in the US for this indication (Vivaglobin – CSL Behring). SCIG has been used in Europe for about 10 years.

PHARMACOKINETICS — To achieve the same AUC (area under the plasma concentration-time curve) as IVIG, the cumulative dose of SCIG, which is given more frequently, must be 1.37 times the IV dose. At that dose, SCIG produces serum concentrations of IgG that are lower at peak but higher at trough than IVIG.

CLINICAL STUDIES — Two clinical studies of Vivaglobin use in primary immune deficiency have been published. One was a 6-month open-label study in 60 adults and children from Europe and Brazil with primary immune deficiency, and the other was a 12-month study in 65 adults ... more      

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Title: Subcutaneous Immune Globulin (SCIG)
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