The Medical Letter on Drugs and Therapeutics
Fluticasone Furoate (Veramyst) for Allergic Rhinitis
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Fluticasone furoate nasal spray (Veramyst – GSK) is now available for once-daily treatment of seasonal and perennial allergic rhinitis in adults and children ≥2 years old. It is similar to fluticasone propionate nasal spray (Flonase, and others), which is now available generically.

PHARMACOLOGY — In vitro, the binding affinity of fluticasone furoate for the glucocorticoid receptor is 1.7 times that of fluticasone propionate, and it is a more potent inhibitor of inflammatory mediators.1

CLINICAL STUDIES — Fluticasone furoate 110 mcg (2 sprays in each nostril) once daily was evaluated in 3 randomized, double-blind 2-week trials in a total of 886 patients ≥12 years old with seasonal allergic rhinitis (SAR).2-4 In all 3 trials, the active drug was significantly more effective than the nasal spray vehicle in improving ... more      

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