The Medical Letter on Drugs and Therapeutics
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Doripenem (Doribax) - A New Parenteral Carbapenem

Doripenem (Doribax – Ortho-McNeil Janssen), an intravenous (IV) carbapenem antibiotic with a spectrum of activity similar to that of imipenem and meropenem, has been approved by the FDA for treatment of complicated intra-abdominal and urinary tract infections. Use of doripenem for treatment of nosocomial pneumonia, including ventilator-associated pneumonia, is still under FDA review.

ANTIBACTERIAL ACTIVITY — Like imipenem and meropenem, doripenem is active against a broad range of gram-positive, gram-negative and anaerobic pathogens.1 In vitro, it is more active than imipenem and meropenem against Pseudomonas aeruginosa2 and is active against some pseudomonal isolates resistant to the other carbapenems3,4; the clinical significance of this in vitro activity is unknown. Carbapenems have little or no activity ... more      

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