The Medical Letter on Drugs and Therapeutics
Veregen: A Botanical for Treatment of Genital Warts
The full article is available to subscribers Subscriber Login   
Revised 10/17/08: Theophylline was deleted from the pharmacology section; it is not among the components that make up 2.5% of the drug weight. Table 1: 2.3% discontinuation rate due to adverse effects for Veregen (not 5%).

The FDA has approved the marketing of sinecatechins (Veregen – Bradley/Medigene), a botanical drug product, for treatment of external genital and perianal warts. Sinecatechins is a water extract of green tea leaves from Camellia sinensis. It is a mixture of catechins and other green tea components.

PHARMACOLOGYVeregen is available as a 15% ointment; each gram of ointment contains 150 mg of sinecatechins. About 85-95% of the total weight of the drug substance is made up of catechins, and of this more than half is epigallocatechin gallate (EGCg). An additional 2.5% of the drug weight is composed of gallic acid, caffeine and theobromine. The remaining components are undefined botanical constituents of green tea leaves. Systemic exposure to catechins after repeated topical application of Veregen appears to be minimal.

MECHANISM OF ACTION — The mechanism by ... more      

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.

Would you like to read the rest of this article?  Gain access below.

Subscriptions to The Medical Letter on Drugs and Therapeutics include:
  • Print version published and mailed biweekly (26 issues/year)
  • Immediate Online access to current issue and archives from 1988 to the present
  • Mobile access to our mobile site and free apps for iOS, Android and Kindle
  • FREE online per issue CME/CE
Free trial offer
3 Free Issues of The Medical Letter on Drugs and Therapeutics mailed to your home or office PLUS online access.
Try a Free Trial Subscription
Purchase this article:
Title: Veregen: A Botanical for Treatment of Genital Warts
Article code: 1280b
 Electronic, downloadable article - $25