The Medical Letter on Drugs and Therapeutics
Veregen: A Botanical for Treatment of Genital Warts
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Revised 10/17/08: Theophylline was deleted from the pharmacology section; it is not among the components that make up 2.5% of the drug weight. Table 1: 2.3% discontinuation rate due to adverse effects for Veregen (not 5%).

The FDA has approved the marketing of sinecatechins (Veregen – Bradley/Medigene), a botanical drug product, for treatment of external genital and perianal warts. Sinecatechins is a water extract of green tea leaves from Camellia sinensis. It is a mixture of catechins and other green tea components.

PHARMACOLOGYVeregen is available as a 15% ointment; each gram of ointment contains 150 mg of sinecatechins. About 85-95% of the total weight of the drug substance is made up of catechins, and of this more than half is epigallocatechin gallate (EGCg). An additional 2.5% of the drug weight is composed of gallic acid, caffeine and theobromine. The remaining components are undefined botanical constituents of green tea leaves. Systemic exposure to catechins after repeated topical application of Veregen appears to be minimal.

MECHANISM OF ACTION — The mechanism by ... more      

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