The Medical Letter on Drugs and Therapeutics
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Ciclesonide (Omnaris) for Allergic Rhinitis

Ciclesonide (Omnaris – Sepracor/Nycomed), a once-daily corticosteroid nasal spray, is now available for treatment of seasonal allergic rhinitis (SAR) in adults and children ≥6 years old and for perennial allergic rhinitis (PAR) in those ≥12 years old. An orally inhaled formulation of ciclesonide (Alvesco) was recently approved by the FDA for maintenance treatment of asthma, and will be reviewed in a future issue of The Medical Letter.

PHARMACOLOGY — Ciclesonide is a prodrug that is hydrolyzed to des-ciclesonide, a pharmacologically active metabolite, by esterases in the nasal mucosa.

CLINICAL STUDIES — Ciclesonide nasal spray 200 mcg once daily was superior to placebo in adults and adolescents with SAR treated for 2 weeks or PAR treated for 6 weeks, with significant reductions in nasal symptom scores of 27% and 33% from baseline compared to reductions of 17% ... more      

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