The Medical Letter on Drugs and Therapeutics
Lubiprostone (Amitiza) for Irritable Bowel Syndrome with Constipation
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Lubiprostone (Amitiza), which was previously approved for treatment of chronic idiopathic constipation in adults,1 has now also been approved in a lower dose for use in women with irritable bowel syndrome with constipation (IBS-C). Since tegaserod (Zelnorm) has been withdrawn from the market,2 lubiprostone is the only drug approved by the FDA for treatment of this common condition.

IRRITABLE BOWEL SYNDROME — IBS, which is characterized by chronic abdominal pain or discomfort and altered bowel habits, has been reported to occur in about 15% of the US population; it is 2-3 times more frequent in women than in men. IBS-C has generally been treated with diet and fiber when symptoms are mild and with over-the-counter stool softeners and laxatives when symptoms are moderate. The serotonin partial agonist tegaserod (when it was available) was used when constipation ... more      

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Title: Lubiprostone (Amitiza) for Irritable Bowel Syndrome with Constipation
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