The Medical Letter on Drugs and Therapeutics
Tetrabenazine (Xenazine) for Huntington's Chorea
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Tetrabenazine (Xenazine – Ovation Pharmaceuticals), an old drug first synthesized 50 years ago for treatment of schizophrenia,1 was recently approved by the FDA for the treatment of chorea associated with Huntington’s disease. It has been available in other countries for decades.

HUNTINGTON’S DISEASE — Huntington’s disease (HD) is an autosomal dominant, progressive neurodegenerative disorder caused by mutations in the IT-15 gene encoding the huntingtin protein. No available treatment slows the progression of the disease, but targeted treatment of depression, anxiety, cognition and chorea can improve patients’ quality of life. Standard treatments for chorea include benzodiazepines, amantadine (Symmetrel, and others) and antipsychotics such as haloperidol (Haldol, and others), risperidone (Risperdal, and others), ziprasidone (Geodon) and ... more      

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Title: Tetrabenazine (Xenazine) for Huntington's Chorea
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