The Medical Letter on Drugs and Therapeutics
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Alemtuzumab (Campath) Off-Label for Relapsing Multiple Sclerosis

Alemtuzumab (Campath), a genetically engineered, humanized monoclonal antibody currently approved to treat B-cell chronic lymphocytic leukemia (BCLL) and used off-label for induction therapy in solid organ transplants, is now also being tried off-label for treatment of relapsing multiple sclerosis (MS).

DRUGS FOR MS — The current treatments for relapsing forms of MS include interferon beta, glatiramer acetate, mitoxantrone and, more recently, natalizumab.1-3 The development of progressive multi-focal leukoencephalopathy (PML) in several patients treated with natalizumab has led some clinicians to reserve it for patients who either do not tolerate or do not respond to interferon beta or glatiramer acetate. Rituximab (Rituxan) has also been tried off-label for this indication.4

MECHANISM OF ACTION — Alemtuzumab binds CD52, an antigen present ... more      

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