The Medical Letter on Drugs and Therapeutics
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1307
Rufinamide (Banzel) for Epilepsy
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Rufinamide (Banzel – Eisai), a triazole derivative structurally unrelated to other marketed antiepileptic drugs (AEDs), has been approved by the FDA for treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in patients ≥4 years old.

LENNOX-GASTAUT SYNDROME — Lennox-Gastaut syndrome is a severe form of childhood epilepsy characterized by multiple types of seizures, often refractory to any treatment, and mental retardation. Most pediatric neurologists consider valproic acid (Depakene, and others) the first-line treatment for LGS,1,2 but only topiramate (Topamax), lamotrigine (Lamictal, and others) and felbamate (Felbatol) are FDA-approved for use in this disorder.

CLINICAL STUDIES — Approval of rufinamide for use in LGS was based on a randomized, double-blind, placebo-controlled, 12-week add-on trial in 138 ... more      

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