The Medical Letter on Drugs and Therapeutics
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1308
March 23, 2009
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Dexlansoprazole (Kapidex) for GERD and Erosive Esophagitis
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March 23, 2009 (Issue: 1308)

The FDA has approved the proton-pump inhibitor (PPI) dexlansoprazole (Kapidex – Takeda), a delayed-release formulation of the R-enantiomer of lansoprazole (Prevacid – Takeda), for treating and maintaining healing of erosive esophagitis and for treatment of heartburn associated with non-erosive gastro-esophageal reflux disease (GERD). Both enantiomers of lansoprazole are active, but the R-enantiomer is longer acting.1 Lansoprazole is expected to become available generically later this year.2

FORMULATION — Kapidex is formulated as capsules containing dexlansoprazole in 2 types of enteric-coated granules that are soluble at 2 different pHs.The drug is designed to dissolve first in the proximal and then in the distal small intestine.

PHARMACOKINETICS — With a dose of 60 mg, serum concentrations of dexlansoprazole first reach a ... more      

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