The Medical Letter on Drugs and Therapeutics
Fesoterodine (Toviaz) for Overactive Bladder
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The FDA has approved the marketing of fesoterodine (Toviaz – Pfizer), a muscarinic receptor antagonist, for treatment of overactive bladder. It is the sixth antimuscarinic drug approved for this indication.

THE CONDITION — Overactive bladder is a chronic condition associated with urgency, frequency, nocturia and incontinence. It is the most common cause of incontinence in the elderly. Antimuscarinic drugs are the usual treatment for symptoms, but they cause dry mouth and constipation, and can cause confusion in elderly patients.

SUBTYPE SELECTIVITY — Some antimuscarinics are claimed to have greater affinity for muscarinic receptor subtypes involved in bladder contraction than for others. Fesoterodine, however, is not selective for subtypes of muscarinic receptors.1

PHARMACOKINETICS — Fesoterodine is a prodrug. It is well absorbed from ... more      

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Title: Fesoterodine (Toviaz) for Overactive Bladder
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