The Medical Letter on Drugs and Therapeutics
Lacosamide for Epilepsy
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The FDA has approved lacosamide (Vimpat – UCB Pharma) for oral or intravenous (IV) use as add-on therapy in adults with partial-onset seizures.

OTHER DRUGS FOR PARTIAL SEIZURES — Among the older antiepileptic drugs (AEDs), carbamazepine, phenytoin and valproate were traditional first-line treatments for partial seizures. All of the newer agents for epilepsy except felbamate and oxcarbazepine were initially approved as adjunctive therapy for partial seizures. Lamotrigine, topiramate, zonisamide and levetiracetam have a broad spectrum of activity and are now used to treat generalized seizures as well.1

IV formulations are also available for phenytoin, valproate, levetiracetam and phenobarbital.

MECHANISM OF ACTION — Lacosamide is a functional amino acid, structurally related to serine. Its antiepileptic actions appear to be related to slow inactivation ... more      

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Title: Lacosamide for Epilepsy
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