The Medical Letter on Drugs and Therapeutics
Golimumab (Simponi) for Inflammatory Arthritis
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Revised 7/22/09: In the first sentence "humanized" was changed to "human." In Table 1, the source for certolizumab (Cimzia) was changed to "humanized" and the price should have been $1,341.68 (not $3,136.40).

Golimumab (Simponi – Centocor), a fully human anti-tumor necrosis factor (TNF)-α antibody, has been approved by the FDA for the treatment of: (1) moderate to severe active rheumatoid arthritis (RA) in combination with methotrexate; (2) active psoriatic arthritis (PsA) alone or in combination with methotrexate; and (3) active ankylosing spondylitis (AS). Treatment of rheumatoid arthritis was recently reviewed in Treatment Guidelines from The Medical Letter.1

MECHANISM OF ACTION — TNF-α is a pro-inflammatory cytokine that is central in the pathogenesis of many systemic inflammatory disorders. Four recombinant agents that inhibit TNF-α are already available (see Table 1). Like infliximab, certolizumab and adalimumab, golimumab acts by targeting and neutralizing both circulating and membrane-bound TNF-α. Etanercept inhibits only soluble ... more      

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Title: Golimumab (Simponi) for Inflammatory Arthritis
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