The Medical Letter on Drugs and Therapeutics
FROM
ISSUE
1318
Tapentadol (Nucynta) - A New Analgesic
The full article is available to subscribers Subscriber Login   
Revised 8/11/09: In the pharmacokinetics table, the half-life for tapentadol was changed from "24" to "4".

The FDA has approved tapentadol hydrochloride (Nucynta – Ortho-McNeil Janssen) for oral treatment of moderate to severe acute pain in patients ≥18 years old. It has been classified as a Schedule II controlled substance.

PHARMACOLOGY — Tapentadol is a centrally-acting synthetic oral analgesic; it is, like morphine, a mu-opioid receptor agonist and, like tricyclic antidepressants, a norepinephrine reuptake inhibitor. It has some structural similarity to tramadol (Ultram, and others), which is also an opioid receptor agonist and an inhibitor of norepinephrine (and serotonin) reuptake, but is not classified as a controlled substance by the FDA.1

CLINICAL STUDIES — In a randomized, double-blind trial in 400 patients with moderate to severe postoperative dental pain, total pain relief scores over 8 hours with single doses of tapentadol ... more      

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.

Would you like to read the rest of this article?  Gain access below.

Subscribe
Subscriptions to The Medical Letter on Drugs and Therapeutics include:
  • Print version published and mailed biweekly (26 issues/year)
  • Immediate Online access to current issue and archives from 1988 to the present
  • Mobile access to our mobile site and free apps for iOS, Android and Kindle
  • FREE online per issue CME/CE
Free trial offer
3 Free Issues of The Medical Letter on Drugs and Therapeutics mailed to your home or office PLUS online access.
Try a Free Trial Subscription
Purchase this article:
Title: Tapentadol (Nucynta) - A New Analgesic
Article code: 1318a
 Electronic, downloadable article - $25