The Medical Letter on Drugs and Therapeutics
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1319
Insulin Glargine (Lantus) and Cancer Risk
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Several large European observational studies published on-line this summer have raised questions about whether use of insulin glargine increases the risk of cancer.

GLARGINE — Insulin glargine (Lantus – Sanofi Aventis) is one of 3 basal insulins marketed in the US. Insulin detemir (Levemir) and NPH (Humulin N; Novolin N) are the others. Insulin glargine is a recombinant DNA analog of human insulin; it forms microprecipitates in subcutaneous tissue, delaying absorption and prolonging its duration of action to 22 ± 4 hours, which makes it the longest-acting basal insulin.1

DIABETES AND CANCER — Type 2 diabetes has been associated with an increased risk of breast cancer (20%), colon cancer (30%) and pancreatic cancer (50%); type 1 diabetes has not been associated with an increase in the incidence of these tumors. Type 2 diabetes is also associated ... more      

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