The Medical Letter on Drugs and Therapeutics
Calcitriol (Vectical) for Mild to Moderate Plaque Psoriasis
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The FDA has approved calcitriol ointment (Vectical – Galderma), a vitamin D analog, for topical treatment of mild-to-moderate plaque psoriasis in adults ≥18 years old. Ointments are generally considered more potent than creams or solutions.

MECHANISM OF ACTION — Calcitriol is a synthetic form of the active metabolite of vitamin D3. It has anti-proliferative, prodifferentiating and immunomodulating effects on human keratinocytes.1

CLINICAL STUDIES — In 2 randomized, doubleblind trials in a total of 839 patients with chronic mildto- moderate plaque psoriasis, patients applied calcitriol ointment or vehicle ointment twice daily for 8 weeks. Treatment success (minimal disease or clear at 8 weeks) occurred in 34.4% and 33.3% of patients with calcitriol in the 2 studies, and in 22.5% and 12.3% with the vehicle.2

No studies are ... more      

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Title: Calcitriol (Vectical) for Mild to Moderate Plaque Psoriasis
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