The Medical Letter on Drugs and Therapeutics
Subscribers: Log in to read full article.  Not a subscriber?  Subscribe or purchase article.

Resveratrol is a phytochemical found in the skin of red grapes and in many other plants, including berries, plums and peanuts. As a constituent of red wine, it has been associated with cardioprotective effects. Dietary supplements containing resveratrol are now being widely promoted as antioxidants that can prevent agerelated diseases.

MECHANISM OF ACTION — Resveratrol increases the activity of some sirtuin enzymes thought to be involved in regulation of molecular mechanisms of aging.1 Caloric restriction also increases sirtuin activity, and long-term adherence to a calorie-restricted diet delayed the onset of age-related diseases and extended lifespan in monkeys.2 Resveratrol has been shown to extend the sirtuin-dependent lifespan of simple organisms such as yeast by up to 70%.3

STUDIES — Oral treatment with resveratrol in ... more      

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.

Would you like to read the rest of this article?  Gain access below.

Subscriptions to The Medical Letter on Drugs and Therapeutics include:
  • Print version published and mailed biweekly (26 issues/year)
  • Unlimited online access to current and past issues (1988 - present)
  • Mobile App for iOS, Android, and Kindle Fire
  • FREE online per issue CME/CE
Purchase this article:
Title: Resveratrol
Article code: 1321b
 Electronic, downloadable article - $45
Gain access through your organization
Ask your librarian to consider an Institutional Subscription to The Medical Letter.
Recommend to your librarian