The Medical Letter on Drugs and Therapeutics
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1321
Resveratrol
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Resveratrol is a phytochemical found in the skin of red grapes and in many other plants, including berries, plums and peanuts. As a constituent of red wine, it has been associated with cardioprotective effects. Dietary supplements containing resveratrol are now being widely promoted as antioxidants that can prevent agerelated diseases.

MECHANISM OF ACTION — Resveratrol increases the activity of some sirtuin enzymes thought to be involved in regulation of molecular mechanisms of aging.1 Caloric restriction also increases sirtuin activity, and long-term adherence to a calorie-restricted diet delayed the onset of age-related diseases and extended lifespan in monkeys.2 Resveratrol has been shown to extend the sirtuin-dependent lifespan of simple organisms such as yeast by up to 70%.3

STUDIES — Oral treatment with resveratrol in ... more      

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Title: Resveratrol
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