The Medical Letter on Drugs and Therapeutics
Tadalafil (Adcirca) for Pulmonary Arterial Hypertension
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The FDA has approved use of tadalafil (Adcirca – Lilly/United Therapeutics) for treatment of pulmonary arterial hypertension (PAH). Tadalafil is also marketed as Cialis for treatment of erectile dysfunction.1

DRUGS FOR PAH — Current management of PAH usually includes warfarin (Coumadin, and others) and furosemide (Lasix, and others). Oral drugs approved for PAH include sildenafil (Revatio), a phosphodiesterase type 5 (PDE5) inhibitor, bosentan (Tracleer), a nonselective endothelin receptor antagonist, and ambrisentan (Letairis), a selective endothelin type A receptor antagonist.2 Patients with more advanced disease can be treated with a systemic prostacyclin such as iloprost (Ventavis) or treprostinil (Tyvaso) given as multiple daily inhalations, or epoprostenol (Flolan) or ... more      

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Title: Tadalafil (Adcirca) for Pulmonary Arterial Hypertension
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