The Medical Letter on Drugs and Therapeutics
Ophthalmic Besifloxacin (Besivance)
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The FDA has approved the fluoroquinolone besifloxacin 0.6% ophthalmic suspension (Besivance – Bausch & Lomb) for treatment of bacterial conjunctivitis caused by susceptible bacteria. According to the manufacturer, this product was developed specifically for ophthalmic use in a specialized vehicle designed to prolong contact time on the ocular surface. Besifloxacin is not available for systemic use.

OTHER OPHTHALMIC ANTIBACTERIALS — Ophthalmic formulations of antibacterial drugs achieve high concentrations on the surface of the eye and may be effective clinically even when organisms are reported to be resistant in vitro.

Sulfacetamide is widely used, but can cause contact sensitivity reactions and rarely has caused Stevens- Johnson syndrome. Neomycin also causes sensitization and other local reactions in about 5-10% of patients. Chloramphenicol ... more      

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Title: Ophthalmic Besifloxacin (Besivance)
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