The Medical Letter on Drugs and Therapeutics
Intravenous Ibuprofen (Caldolor)
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An intraveneous (IV) formulation of ibuprofen (Caldolor – Cumberland) was recently approved by the FDA for use in adults. It can be administered alone for treatment of mild to moderate pain or as an adjunct to opioid analgesics for moderate to severe pain. It is also approved for reduction of fever.

NSAIDS FOR PAIN — Use of a nonsteroidal anti-inflammatory drug (NSAID) in addition to an opioid analgesic for management of postoperative pain has been shown to improve pain control and reduce opioid use,1 but administration of an oral NSAID may not be possible during or immediately after surgery. Ketorolac (Toradol, and others), the only other NSAID available in an injectable formulation for use as an analgesic, can cause severe gastrointestinal toxicity and is not recommended for more than 5 days’ use. Indomethacin is available for IV use in closure of a patent ... more      

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Title: Intravenous Ibuprofen (Caldolor)
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