The Medical Letter on Drugs and Therapeutics
Bepotastine (Bepreve) - An Ophthalmic H1-Antihistamine
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Bepotastine besilate 1.5% ophthalmic solution (Bepreve – ISTA Pharmaceuticals), an H1-antihistamine, has been approved by the FDA for topical treatment of itching associated with allergic conjunctivitis in patients ≥2 years old. Bepotastine was first developed in an oral systemic formulation and has been used as such for treatment of allergic rhinitis in Japan.

TREATMENT OF ALLERGIC CONJUNCTIVITIS — Allergic conjunctivitis is the most common form of ocular allergy. The main symptom of itching can be relieved by oral H1-antihistamines such as cetirizine (Zyrtec, and others; available over the counter), desloratadine (Clarinex), fexofenadine (Allegra, and others) or loratadine (Claritin, and others; available over the counter). Ophthalmic antihistamines are also effective and have a more rapid onset of action than the oral drugs. Ketotifen (which is ... more      

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