The Medical Letter on Drugs and Therapeutics
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Iloperidone (Fanapt) - Another Second-Generation Antipsychotic



The FDA has approved the marketing of iloperidone (Fanapt – Vanda), a second-generation antipsychotic, for treatment of schizophrenia. Iloperidone is chemically related to risperidone (Risperdal, and others).

DRUGS FOR SCHIZOPHRENIA — First-generation antipsychotic agents block dopamine D2 receptors. Second-generation antipsychotics combine D2 and serotonin 5HT2A antagonism. Controlled trials have failed to demonstrate clear advantages in efficacy with the second-generation antipsychotics compared to less expensive first-generation drugs, except with clozapine, which has life-threatening adverse effects, and possibly with olanzapine, which has substantial adverse metabolic effects (REF 1,2). The second-generation drugs do have a relatively low ... more      

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