The Medical Letter on Drugs and Therapeutics
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1333
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Rosiglitazone (Avandia) Revisited

The cardiovascular safety of the thiazolidinedione rosiglitazone (Avandia – GlaxoSmithKline) is in the news again, with some authorities calling for its removal from the market (New York Times, February 19, 2010).

THIAZOLIDINEDIONES — The thiazolidinediones rosiglitazone and pioglitazone (Actos) are insulin sensitizing agents used to treat hyperglycemia in patients with type 2 diabetes. They are often used as a second or third agent with metformin (Glucophage, and others) and/or a sulfonylurea such as glimepiride (Amaryl, and others).1 Both rosiglitazone and pioglitazone can cause edema and weight gain and increase the risk of congestive heart failure.

AN OPEN-LABEL RANDOMIZED TRIAL — Among 4447 previously treated patients randomly assigned either to rosiglitazone added as a second drug to metformin or a sulfonylurea, or to metformin plus ... more      

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