The Medical Letter on Drugs and Therapeutics
Hyperbaric Oxygen Therapy for Refractory Wounds
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Hyperbaric oxygen (HBO2) therapy, breathing 100% O2 while exposed to increased atmospheric pressure, has been used for years to treat refractory wounds, especially diabetic foot ulcers.1

MECHANISM OF ACTION — HBO2 raises hydrostatic pressure and the partial pressure of O2. Increasing hydrostatic pressure causes a reduction in the volume of gas-filled spaces and prevents downstream vasoconstriction. Increasing oxygen partial pressures in body fluids increases oxygenation of tissues. HBO2 also reduces circulating levels of pro-inflammatory cytokines, increases synthesis of vascular endothelial growth factor (VEGF) and proliferation of fibroblasts, stimulates angiogenesis, and mobilizes stem/progenitor cells that accelerate healing.2,3

CLINICAL STUDIES — HBO2 is used in current practice mainly ... more      

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Title: Hyperbaric Oxygen Therapy for Refractory Wounds
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