The Medical Letter on Drugs and Therapeutics
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1334
A Morphine/Naltrexone Combination (Embeda) for Pain
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The FDA has approved an agonist/antagonist combination of morphine and naltrexone (Embeda – King) for treatment of chronic moderate to severe pain requiring around-the-clock analgesia for an extended period of time. The addition of naltrexone is intended to prevent abuse of morphine.

MECHANISM OF ACTION — Naltrexone (ReVia, and others) is an opioid receptor antagonist known to block the pharmacologic effects of morphine. The new combination is formulated as capsules of extended-release morphine pellets that contain a sequestered core of naltrexone. If the pellets are swallowed, the morphine is gradually released and absorbed, while the naltrexone core should pass through the gut intact. If the pellets are crushed, chewed or dissolved in an attempt to release all of the morphine at once, naltrexone would also be released and should block morphine-induced euphoria.

PHARMACOKINETICS ... more      

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Title: A Morphine Naltrexone Combination (Embeda) for Pain
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