The Medical Letter on Drugs and Therapeutics
Ferumoxytol (Feraheme) - A New Parenteral Iron Formulation
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Revised 4/13/10: The last sentence of the Dosage, Administration and Cost paragraph should have listed the cost of 1 gram of sodium ferric gluconate (Ferrlecit) as about $600.

Revised 4/24/15: Since this article was published, new information about the risk of anaphylaxis has become available.

Ferumoxytol (Fer yoo mox’ i tole; Feraheme – AMAG), an intravenous (IV) iron replacement product, has been approved by the FDA for treatment of iron deficiency anemia in adults with chronic kidney disease. Iron deficiency anemia is common in chronic kidney disease and may be associated with decreased absorption from the gastrointestinal tract, limiting the usefulness of oral iron replacement. IV iron replacement can lower the dose requirement for erythropoiesis-stimulating drugs, particularly in patients on dialysis.1

IV IRON FORMULATIONS — Four other FDA-approved injectable iron products are already available in the US: high molecular weight iron dextran (Dexferrum), low molecular weight iron dextran (INFeD), sodium ferric gluconate (Ferrlecit), and iron sucrose (Venofer). High molecular weight iron dextran has been associated with a high incidence of ... more      

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Title: Ferumoxytol (Feraheme) - A New Parenteral Iron Formulation
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