The Medical Letter on Drugs and Therapeutics
Plerixafor (Mozobil)
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The FDA has approved plerixafor (Mozobil – Genzyme), a CXCR4 chemokine receptor antagonist, for use in combination with granulocyte-colony stimulating factor (G-CSF; Neupogen) to mobilize peripheral blood stem cells in adults with multiple myeloma or non-Hodgkin’s lymphoma before high-dose chemotherapy with autologous stem cell rescue.

STANDARD TREATMENT — High-dose chemotherapy can overcome mechanisms of resistance to conventional chemotherapy, increasing survival rates of multiple myeloma and possibly curing some subtypes of non-Hodgkin’s lymphoma. G-CSF is the agent most commonly used to mobilize peripheral blood stem cells for harvest in preparation for high-dose chemotherapy, but some patients with non-Hodgkin’s lymphoma or multiple myeloma fail to mobilize a sufficient number of cells with G-CSF alone.1

MECHANISM OF ACTION — Plerixafor is ... more      

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Title: Plerixafor (Mozobil)
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