The Medical Letter on Drugs and Therapeutics
L-Methylfolate (Deplin) for Depression and Schizophrenia
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L-methylfolate (Deplin — Pamlab) is a “medical food” marketed for adjunctive use in depression or schizophrenia in patients with suboptimal folate levels.1 It is available only by prescription.

MEDICAL FOODS — The Orphan Drug Act Amendments of 1988 define a medical food as “a food which is formulated to be consumed or administered enterally under the supervision of a physician, and which is intended for the specific dietary management of a disease or condition for which distinctive nutritional requirements, based on recognized scientific principles, are established by medical evaluation.” Medical foods are exempt from labeling requirements for health claims and nutrient content. They are regulated, but not registered, reviewed or approved, by the FDA.

RATIONALE — The primary suggested mechanism of action claimed for L-methylfolate in depression is that it aids ... more      

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Title: L-Methylfolate (Deplin) for Depression and Schizophrenia
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