The Medical Letter on Drugs and Therapeutics
Everolimus and Pazopanib: Two New Drugs for Renal Cell Cancer
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Everolimus (Afinitor – Novartis) and pazopanib (Votrient – GlaxoSmithKline), two oral multikinase inhibitors, have been approved by the FDA for treatment of advanced renal cell carcinoma. Sunitinib (Sutent) and sorafenib (Nexavar), two other oral multikinase inhibitors, and temsirolimus (Torisel), an IV multikinase inhibitor, were approved earlier for the same indication.1,2

TREATMENT OF RENAL CELL CANCER — The preferred treatment for renal cell cancer is surgical resection. Chemotherapy is generally used for patients whose disease has metastasized. Agents that prevent angiogenesis and tumor proliferation through inhibition of the vascular endothelial growth factor (VEGF) or mammalian target of rapamycin (mTOR) pathways have now become the standard of care.3

EVEROLIMUS — An mTOR inhibitor, everolimus has ... more      

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Title: Everolimus and Pazopanib: Two New Drugs for Renal Cell Cancer
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