The Medical Letter on Drugs and Therapeutics
Cost of Topical Products for Tinea Pedis
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A Medical Letter reader recently received a diagnosis of athlete’s foot and a prescription for Naftin gel, for which his pharmacy charged $145, and his insurance company required a $70 copay because this formulation was not included in its formulary. Do patients need to pay prices like these to treat tinea pedis?

DRUGS FOR TINEA PEDIS — Most dermatologists prescribe either an allylamine, benzylamine or imidazole topical antifungal to treat tinea pedis. All three inhibit synthesis of ergosterol, an essential component of fungal cell membranes. Allylamines are more active in vitro than imidazoles against the dermatophytes that cause the disease.

CLINICAL TRIALS — Only a few clinical trials have compared topical antifungal drugs with each other, and none have found the sponsor’s drug inferior to the comparator. A 1993 double-blind randomized trial (sponsored by the manufacturer ... more      

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Title: Cost of Topical Products for Tinea Pedis
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