The Medical Letter on Drugs and Therapeutics
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1339
Romidepsin (Istodax) for Cutaneous T-Cell Lymphoma
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The FDA has approved romidepsin (Istodax – Celgene), an IV histone deacetylase (HDAC) inhibitor, for treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. The most common types of CTCL are mycosis fungoides, a low-grade lymphoma usually confined to the skin, and Sézary syndrome, a more aggressive disease with malignant lymphocytes in the blood. Both can progress to fatal systemic involvement.1 Romidepsin is the second HDAC inhibitor approved for this indication; vorinostat (Zolinza), an oral HDAC inhibitor, was approved earlier.2

STANDARD TREATMENT — Early-stage CTCL can usually be controlled with skin-directed therapies such as topical nitrogen mustard, corticosteroids and retinoids, phototherapy (UVB, PUVA) or radiation. For more advanced stages, FDA-approved systemic therapies include vorinostat, ... more      

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Title: Romidepsin (Istodax) for Cutaneous T-Cell Lymphoma
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